Community Wind 101: A Primer for Policymakers

Provides an overview of a model for wind power development based on local ownership. Reviews innovative examples, economic benefits for the community, benefits for clean energy development, obstacles, and state and federal policy options to address them

The cnidarian-bilaterian ancestor possessed at least 56 homeoboxes: evidence from the starlet sea anemone, Nematostella vectensis

BACKGROUND: Homeodomain transcription factors are key components in the developmental toolkits of animals. While this gene superclass predates the evolutionary split between animals, plants, and fungi, many homeobox genes appear unique to animals. The origin of particular homeobox genes may, therefore, be associated with the evolution of particular animal traits. Here we report the first near-complete set of homeodomains from a basal (diploblastic) animal. RESULTS: Phylogenetic analyses were performed on 130 homeodomains from the sequenced genome of the sea anemone Nematostella vectensis along with 228 homeodomains from human and 97 homeodomains from Drosophila. The Nematostella homeodomains appear to be distributed among established homeodomain classes in the following fashion: 72 ANTP class; one HNF class; four LIM class; five POU class; 33 PRD class; five SINE class; and six TALE class. For four of the Nematostella homeodomains, there is disagreement between neighbor-joining and Bayesian trees regarding their class membership. A putative Nematostella CUT class gene is also identified. CONCLUSION: The homeodomain superclass underwent extensive radiations prior to the evolutionary split between Cnidaria and Bilateria. Fifty-six homeodomain families found in human and/or fruit fly are also found in Nematostella, though seventeen families shared by human and fly appear absent in Nematostella. Homeodomain loss is also apparent in the bilaterian taxa: eight homeodomain families shared by Drosophila and Nematostella appear absent from human (CG13424, EMXLX, HOMEOBRAIN, MSXLX, NK7, REPO, ROUGH, and UNC4), and six homeodomain families shared by human and Nematostella appear absent from fruit fly (ALX, DMBX, DUX, HNF, POU1, and VAX)

Pathological features and survival outcomes of very young patients with early breast cancer: How much is "very young"?

Abstract We collected information on 497 consecutive breast cancer patients aged less than 35 years operated at the European Institute of Oncology. The main aim of the study is to compare biological and clinical features dividing the population by age: Patients aged p = 0.79) and overall survival ( p = 0.99) between the three age groups. This latter findings was confirmed using age as a continuous variable assuming a linear association between age and the outcomes considered, too. In conclusion, our data indicate that the group of patients with breast cancer below 35 years is essentially a homogenous group when classical clinical and immunohistochemical features were considered

Self-assembly of liquid crystals in nanoporous solids for adaptive photonic metamaterials

Nanoporous media exhibit structures significantly smaller than the wavelengths of visible light and can thus act as photonic metamaterials. Their optical functionality is not determined by the properties of the base materials, but rather by tailored, multiscale structures, in terms of precise pore shape, geometry, and orientation. Embedding liquid crystals in pore space provides additional opportunities to control light-matter interactions at the single-pore, meta-atomic scale. Here, we present temperature-dependent 3D reciprocal space mapping using synchrotron-based X-ray diffraction in combination with high-resolution birefringence experiments on disk-like mesogens (HAT6) imbibed in self-ordered arrays of parallel cylindrical pores 17 to 160nm across in monolithic anodic aluminium oxide (AAO). In agreement with Monte Carlo computer simulations we observe a remarkably rich self-assembly behaviour, unknown from the bulk state. It encompasses transitions between the isotropic liquid state and discotic stacking in linear columns as well as circular concentric ring formation perpendicular and parallel to the pore axis. These textural transitions underpin an optical birefringence functionality, tuneable in magnitude and in sign from positive to negative via pore size, pore surface-grafting and temperature. Our study demonstrates that the advent of large-scale, self-organised nanoporosity in monolithic solids along with confinement-controllable phase behaviour of liquid-crystalline matter at the single-pore scale provides a reliable and accessible tool to design materials with adjustable optical anisotropy, and thus offers versatile pathways to fine-tune polarisation-dependent light propagation speeds in materials. Such a tailorability is at the core of the emerging field of transformative optics, allowing, e.g., adjustable light absorbers and extremely thin metalenses.Deutsche Forschungsgemeinschaft (DFG, German Research Foundation

Linear Logic by Levels and Bounded Time Complexity

We give a new characterization of elementary and deterministic polynomial time computation in linear logic through the proofs-as-programs correspondence. Girard's seminal results, concerning elementary and light linear logic, achieve this characterization by enforcing a stratification principle on proofs, using the notion of depth in proof nets. Here, we propose a more general form of stratification, based on inducing levels in proof nets by means of indexes, which allows us to extend Girard's systems while keeping the same complexity properties. In particular, it turns out that Girard's systems can be recovered by forcing depth and level to coincide. A consequence of the higher flexibility of levels with respect to depth is the absence of boxes for handling the paragraph modality. We use this fact to propose a variant of our polytime system in which the paragraph modality is only allowed on atoms, and which may thus serve as a basis for developing lambda-calculus type assignment systems with more efficient typing algorithms than existing ones.Comment: 63 pages. To appear in Theoretical Computer Science. This version corrects minor fonts problems from v

Pegylated liposomal doxorubicin in combination with low-dose metronomic cyclophosphamide as preoperative treatment for patients with locally advanced breast cancer.

Abstract Aim To evaluate the role of pegylated liposomal doxorubicin with low-dose metronomic cyclophosphamide as primary systemic treatment in locally advanced breast cancer. Patients and Methods The activity and safety of intravenous pegylated liposomal doxorubicin 20 mg sqm−1 biweekly for eight courses in combination with metronomic cyclophosphamide 50 mg day−1 orally were evaluated in 29 patients with locally advanced breast cancer who were not suitable to receive a standard chemotherapy due to age or co-morbidities or who asked for a regimen with low incidence of toxic effects irrespective of age. Results The rate of breast-conserving surgery was 44.8%. Eighteen patients (62.1%) achieved a partial response (including one pathological complete response), 10 (34.5%) a stable disease and one patient experienced a progressive disease. Treatment was well tolerated, with no grade 4 toxicities, and with grade 3 skin toxicity in three patients and hand–foot syndrome in four patients. Conclusion The regimen was well tolerated but with limited activity in the preoperative setting. Other options (e.g., endocrine therapy in estrogen receptor -positive disease) should be considered in locally advanced breast cancer patients who are not suitable to receive a standard chemotherapy

Preclinical modeling of chronic inhibition of the Parkinson’s disease associated kinase LRRK2 reveals altered function of the endolysosomal system in vivo

The most common mutation in the Leucine-rich repeat kinase 2 gene (LRRK2), G2019S, causes familial Parkinson’s Disease (PD) and renders the encoded protein kinase hyperactive. While targeting LRRK2 activity is currently being tested in clinical trials as a therapeutic avenue for PD, to date, the molecular effects of chronic LRRK2 inhibition have not yet been examined in vivo. We evaluated the utility of newly available phospho-antibodies for Rab substrates and LRRK2 autophosphorylation to examine the pharmacodynamic response to treatment with the potent and specific LRRK2 inhibitor, MLi-2, in brain and peripheral tissue in G2019S LRRK2 knock-in mice. We report higher sensitivity of LRRK2 autophosphorylation to MLi-2 treatment and slower recovery in washout conditions compared to Rab GTPases phosphorylation, and we identify pS106 Rab12 as a robust readout of downstream LRRK2 activity across tissues. The downstream effects of long-term chronic LRRK2 inhibition in vivo were evaluated in G2019S LRRK2 knock-in mice by phospho- and total proteomic analyses following an in-diet administration of MLi-2 for 10 weeks. We observed significant alterations in endolysosomal and trafficking pathways in the kidney that were sensitive to MLi-2 treatment and were validated biochemically. Furthermore, a subtle but distinct biochemical signature affecting mitochondrial proteins was observed in brain tissue in the same animals that, again, was reverted by kinase inhibition. Proteomic analysis in the lung did not detect any major pathway of dysregulation that would be indicative of pulmonary impairment. This is the first study to examine the molecular underpinnings of chronic LRRK2 inhibition in a preclinical in vivo PD model and highlights cellular processes that may be influenced by therapeutic strategies aimed at restoring LRRK2 physiological activity in PD patients

An Optical Fiber Viscometer Based on Long-Period Fiber Grating Technology and Capillary Tube Mechanism

This work addresses the development and assessment of a fiber optical viscometer using a simple and low-cost long-period fiber grating (LPFG) level sensor and a capillary tube mechanism. Previous studies of optical viscosity sensors were conducted by using different optical sensing methods. The proposed optical viscometer consists of an LPFG sensor, a temperature-controlled chamber, and a cone-shaped reservoir where gravitational force could cause fluid to flow through the capillary tube. We focused on the use of LPFGs as level sensors and the wavelength shifts were not used to quantify the viscosity values of asphalt binders. When the LPFG sensor was immersed in the constant volume (100 mL) AC-20 asphalt binder, a wavelength shift was observed and acquired using LabVIEW software and GPIB controller. The time spent between empty and 100 mL was calculated to determine the discharge time. We simultaneously measured the LPFG-induced discharge time and the transmission spectra both in hot air and AC-20 asphalt binder at five different temperatures, 60, 80, 100, 135, and 170 Celsius. An electromechanical rotational viscometer was also used to measure the viscosities, 0.15–213.80 Pa·s, of the same asphalt binder at the above five temperatures. A non-linear regression analysis was performed to convert LPFG-induced discharge time into viscosities. Comparative analysis shows that the LPFG-induced discharge time agreed well with the viscosities obtained from the rotational viscometer

Influência dos fatores individuais, relativos ao trabalho e organizacionais na adesão às precauções padrão por profissionais da odontologia

Background and Objectives: Individual, work-related and organizational factors can enhance the adherence of safe practices in work environment in order to prevent the occurrence of exposure to biological material among health professionals. Based on this, the aim of this study was to verify the influence of individual, work-related and organizational factors in the adherence to standard precautions. Methods: This was a cross-sectional study of character census, conducted with 79 dental professionals (dentists and dental assistants), allocated in the public health system of an outback city in Sao Paulo State. The participants answered the explanatory model of adherence to standard precautions. It’s a validated questionnaire, consisting of demographic variables and psychometric scales, where the combination of these factors and adherence to standard precautions was obtained by multiple logistic regression analysis. Results: Statistical analysis revealed that professional age, time in the profession and in unity, how became aware of standard precautions, personality of risk, prevention efficacy, barriers to follow standard precautions, training and availability of personal protective equipment, management actions to support worker safety, feedback of safety practices and knowledge of occupational transmission of HIV; beyond workload, positively influenced the adherence to standard precautions among professional members of the study. Conclusion: It is concluded that adherence to standard precautions is influenced, simultaneously, by individual, work-related and organizational factors.Justificativa e Objetivos: Os fatores individuais, relativos ao trabalho e organizacionais podem favorecer a adesão de práticas seguras no ambiente laboral, prevenindo a ocorrência de exposições a material biológico entre profissionais da área da saúde. Baseado nisso, objetivou-se verificar a influência de fatores individuais, relativos ao trabalho e organizacionais na adesão às precauções padrão. Métodos: Trata-se de um estudo transversal, de caráter censitário, com abordagem quantitativa, realizado com 79 profissionais da área odontológica (cirurgiões-dentistas e auxiliares em saúde bucal), alocados no sistema público de saúde de um município do interior paulista. Para coleta dos dados, os participantes responderam ao modelo explicativo da adesão às precauções padrão. Trata-se de um questionário validado, constituído por variáveis demográficas e escalas psicométricas, onde a associação destes fatores com a adesão às precauções padrão foi obtida por meio da análise de regressão logística múltipla. Resultados: A análise estatística revelou que a idade do profissional, o tempo de atuação na profissão e de trabalho na unidade; a forma como tomou conhecimento das precauções padrão, a personalidade de risco, a eficácia da prevenção, os obstáculos para seguir as precauções padrão, o treinamento e disponibilidade do equipamento de proteção individual; as ações gerenciais de apoio a segurança do trabalhador, o feedback das práticas seguras e conhecimento da transmissão ocupacional do HIV; além da carga de trabalho, influenciaram positivamente na adesão às precauções padrão entre os profissionais integrantes do estudo. Conclusão: Conclui-se que a adesão às precauções padrão é influenciada, simultaneamente, por fatores individuais, relativos ao trabalho e organizacionais